Endocrine Abstracts

Introduction: Congenital nephrotic syndrome (CNS) is defined as heavy proteinuria starting within three months after birth. It affects approximately 1 to 3 per 100 000 children worldwide. The classical form is the Finnish type, caused by mutations in the nephrin gene. Approximately 50 percent of all nephrotic patients have low total thyroxine (T4) concentrations resulting from urinary losses of T4-binding globulin (TBG) and other thyroid hormone-binding protei...